Chlamydia psittaci pneumonia in Wuxi, China: retrospective analysis of 55 cases and predictors of severe disease

Purpose More and more patients with community-acquired pneumonia have been detected Chlamydia psittaci ( C. ) infected using metagenomic next-generation sequencing (mNGS). Previously, this was unheard of, several presented severe even required ECMO. We aimed to clarify the clinical characteristics of find out if there are any possible predictors pneumonia. Methods In retrospective study, we included all confirmed cases in Wuxi. Epidemiological, clinical, radiological features, as well laboratory data, were collected analyzed. Results enrolled 55 pneumonia, 30 (54.5%) having a history exposure birds or their internal organs. 50 (90.9%) diagnosed by mNGS. Patients had many complications, among which, that deserve sufficient attention from clinicians vascular embolic events (3, 5.5%). High fever most common manifestation (41, 74.5%). The majority significant increase neutrophils ratio, lymphocytes ratio (NLR), rapid c-reactive protein, creatine kinase (CK), lactate dehydrogenase (LDH), decrease albumin, serum sodium, potassium, phosphorus. Chest computed tomography scans revealed unilateral (70.9%), consolidation (87.3%), air bronchogram (76.4%), ground-glass opacity (69.1%). neutrophil NLR, LDH, CK factors could identify Both AUCs exceeded 0.8; respective 95% CIs 0.715–0.944, 0.710–0.963, 0.677–0.937, 0.718–0.950; p < 0.05 (0.01, 0.001, 0.007, 0.007 respectively). ORs 10.057, 9.750, 9.667, respectively; 2.643–38.276, 2.339–40.649, -values less than (0.001, 0.002, 0.001 Conclusion is very complex disease changes time. Some showed will poor prognosis they not treated promptly effectively. discovered indicators typical. Meanwhile, increases predicted Timely detection mNGS provided substantial help for diagnosis early treatment.